Modulation of the Cardiac Transient Outward Potassium Current by Alpha1-Adrenoceptors Requires Caveolae Integrity

Modulation of human cardiac transient outward potassium current by EGFR tyrosine kinase and Src-family kinases.

AIMS The human cardiac transient outward K(+) current I(to) (encoded by Kv4.3 or KCND3) plays an important role in phase 1 rapid repolarization of cardiac action potentials in the heart. However, modulation of I(to) by intracellular signal transduction is not fully understood. The present study was therefore designed to determine whether/how human atrial I(to) and hKv4.3 channels stably express...

Transient outward potassium current in ICC.

Interstitial cells of Cajal (ICC) are the pacemakers of the gut, initiating slow-wave activity. Several ion channels have been identified that contribute to the depolarization phase of the slow wave. Our aim was to contribute to knowledge about the identity and role of ICC potassium channels in pacemaking. Here we describe a transient outward potassium current in cell-attached patches of ICC. T...

Title Modulation of human cardiac transient outward potassium current by EGFR tyrosine kinase and Src-family kinases

Role of the transient outward potassium current in the genesis of early afterdepolarizations in cardiac cells.

AIMS The transient outward potassium current (I(to)) plays important roles in action potential (AP) morphology and dynamics; however, its role in the genesis of early afterdepolarizations (EADs) is not well understood. We aimed to study the effects and mechanisms of I(to) on EAD genesis in cardiac cells using combined experimental and computational approaches. METHODS AND RESULTS We first car...

Molecular aspects of adrenergic modulation of the transient outward current.

Transient outward channels have a different impact on action potential configuration in small mammals compared to large mammals. Small mammals depend primarily on Ito1 for repolarization, while in larger animals Ito1 only indirectly determines action potential duration by setting the level of the plateau. Transient outward channel expression and distribution also differ between animal species. ...